Table 4 Association between exposure to SARS-CoV-2 during pregnancy exposure period and maternal outcomes, calculated using conditional logistic regression

From: Neonatal and maternal outcomes following SARS-CoV-2 infection and COVID-19 vaccination: a population-based matched cohort study

Cohort (Outcome)

Infection status

Number of pregnancies/ neonates

Number with outcome

% with outcome

Odds ratio accounting for only matchinga [95% CI]

P valuea

Adjusted odds ratiob [95% CI]

P valueb

7 (Critical care and/or Death)

Infected

4074

175

4.3%

1.83 [1.51-2.21]

<0.001

1.72 [1.39-2.12]

<0.001

 

Uninfected

12222

290

2.4%

Ref

–

Ref

–

8 (Venous thromboembolism)

Infected

4072

29

0.7%

2.72 [1.65–4.49]

<0.001

2.53 [1.47–4.35]

<0.001

 

Uninfected

12216

32

0.3%

Ref

–

Ref

–

9 (Hypertensive disorders of pregnancy)

Infected

4071

178

4.4%

0.85 [0.72-1.01]

0.06

0.82 [0.68-0.98]

0.03

 

Uninfected

12213

624

5.1%

Ref

–

Ref

–

10 (Pregnancy-related bleeding)

Infected

3973

1665

41.9%

0.96 [0.90-1.05]

0.33

0.97 [0.90-1.04]

0.39

 

Uninfected

11919

5101

42.8%

Ref

–

Ref

–

  1. CI confidence interval
  2. aMatched for maternal age, gestation at infection/matching and seasons of conception and additionally for health board of residence (Greater Glasgow & Clyde or Lanarkshire versus all other health boards) for hypertensive disorders of pregnancy and pregnancy-related bleeding.
  3. bAdjustment for parity and deprivation only for analyses with the following outcomes: venous thromboembolism. Adjustment for all covariates for analyses for the following outcomes: maternal critical care or death, hypertensive disorders of pregnancy and pregnancy-related bleeding.
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