Table 6 Association between exposure to COVID-19 vaccination during pregnancy exposure period and maternal outcomes, calculated using conditional logistic regression

From: Neonatal and maternal outcomes following SARS-CoV-2 infection and COVID-19 vaccination: a population-based matched cohort study

Cohort (outcome)

Vaccination Status

Number of pregnancies/ neonates

Number with outcome

% with outcome

Odds ratio accounting for only matchinga [95% CI]

P valuea

Adjusted odds ratiob [95% CI]

P valueb

7 (Critical care and/or Death)

Vaccinated

11379

253

2.2%

0.92 [0.79–1.07]

0.26

0.86 [0.73–1.01]

0.07

 

Unvaccinated

22758

551

2.4%

Ref

–

Ref

–

8 (Venous thromboembolism)

Vaccinated

11375

17

0.1%

0.60 [0.35–1.04]

0.07

0.62 [0.35–1.09]

0.10

 

Unvaccinated

22750

56

0.2%

Ref

–

Ref

–

9 (Hypertensive disorders of pregnancy)

Vaccinated

11373

638

5.6%

0.99 [0.90–1.10]

0.89

0.89 [0.80–0.99]

0.04

 

Unvaccinated

22746

1284

5.6%

Ref

–

Ref

–

10 (Pregnancy-related bleeding)

Vaccinated

11230

5195

46.3%

1.09 [1.04–1.14]

<0.001

1.04 [0.99–1.09]

0.14

 

Unvaccinated

22460

9900

44.1%

Ref

–

Ref

–

  1. CI confidence interval
  2. aMatched for maternal age and gestation at vaccination/matching and additionally for health board of residence (Greater Glasgow & Clyde or Lanarkshire versus all other health boards) for hypertensive disorders of pregnancy and pregnancy-related bleeding.
  3. bAdjustment for parity and deprivation only for analyses with the following outcomes: venous thromboembolism. Adjustment for all covariates for analyses for the following outcomes: maternal critical care or death, hypertensive disorders of pregnancy and pregnancy-related bleeding.
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