Fig. 3: Analysis of circulating T cells expressing markers of exhaustion and T-cell receptor repertoire diversity.
From: Immunophenotypic correlates of sustained MRD negativity in patients with multiple myeloma
a Abundance of terminal effector memory T cells (TEM) expressing known exhaustion markers in cancer. b The mean percentage of TOX + TEM cells and standard error at baseline and follow-up according to minimal residual disease (MRD) negative status and transplant history. c Single-cell T-cell receptor mean Gini index and standard error showing the diversity of CD4+ and CD8+ T cells at baseline and follow-up according to MRD-negative status and transplant history. A higher Gini index corresponds to greater receptor diversity. d Circle packing plot showing individual T-cell phenotype (colored circles) in relation to clonotype (light-gray circles) and shared antigen specificity group (dark gray circles). Asterisks indicate a two-sided Wilcoxon rank-sum test P < 0.05. N = 20 sustained MRD- (16 no prior HDM-ASCT, 4 prior HDM-ASCT) and 20 non-sustained MRD- (6 no prior HDM-ASCT, 14 prior HDM-ASCT) patient samples. In the box plot, the ends of the whiskers represent 1.5 times the interquartile range, the center represents the median, and the bounds of the box represent the first and third quartiles. Source data are provided as a Supplementary Data file. HDM-ASCT high-dose melphalan autologous stem cell transplant.
