Fig. 7: Gram-scale experiments and synthetic applications.
From: Cobalt-catalyzed atroposelective C−H activation/annulation to access N−N axially chiral frameworks
a Gram-scale experiments using 1a as substrates and post-functionalization of N–N axially chiral product 3aa and 3ai. ee, enantiomeric excess; DDQ, 2,3-dichloro-5,6-dicyano-1,4-benzoquinone; m-CPBA, 3-chloroperoxybenzoic acid; BSA, N,O-bis(trimethylsilyl)-acetamide; DCM, dichloromethane; THF, tetrahydrofuran; rt, roomtemperature. b Applications of N–N axially chiral compound 4 and 6 as chiral ligands for further applications.
