Fig. 6: Antigenic sites, PVR footprint, and 9H2 summary footprint. | Nature Communications

Fig. 6: Antigenic sites, PVR footprint, and 9H2 summary footprint.

From: A human monoclonal antibody binds within the poliovirus receptor-binding site to neutralize all three serotypes

Fig. 6

Amino acids are numbered as sequence-equivalent residues in an alignment to WTPV1. A Antigenic sites (rodent models) as summarized by Fiore et al. 199723; blue, N-Ag I; red, N-Ag II; yellow, N-Ag III. The 9H2 footprint has 5 non-universal contact residues that overlap with N-Ag I & II. B The footprint of the PV receptor CD155 (cyan)15 has a significant overlap with the 9H2 footprint. C Summary footprint of 9H2. Blue, universal contacts in all 9H2 complexes (VP1 T88, I89, A106, V107, W108, D114, E168, L228; VP3 A235); red, non-universal contacts. The canyon (black) and CD 155 footprint (cyan) are indicated. D Roadmap has been colored by radius from the center of the virus. Color key in Å.

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