Fig. 3: FMD modulates tumor infiltrating myeloid cells. | Nature Communications

Fig. 3: FMD modulates tumor infiltrating myeloid cells.

From: Fasting mimicking diet in mice delays cancer growth and reduces immunotherapy-associated cardiovascular and systemic side effects

Fig. 3

A CD45+CD11c+MHCII+ dendritic cell (AL NT n = 5; FMD NT n = 7; AL anti-OX40/anti-PD-L1 n = 5; FMD anti-OX40/anti-PD-L1 n = 9; B CD45+CD11b+F4/80high macrophage (AL NT n = 4; FMD NT n = 7; AL anti-OX40/anti-PD-L1 n = 5; FMD anti-OX40/anti-PD-L1 n = 7); C CD45+CD11b+Ly6Chigh M-MDSC (AL NT n = 5; FMD NT n = 7; AL anti-OX40/anti-PD-L1 n = 5; FMD anti-OX40/anti-PD-L1 n = 9); D CD45+CD11b+Ly6ClowLy6Ghigh PMN-MDSC (AL NT n = 5; FMD NT n = 7; AL anti-OX40/anti-PD-L1 n = 5; FMD anti-OX40/anti-PD-L1 n = 8). Statistical analysis was performed using one-way analysis of variance (ANOVA). P values were determined by one-way ANOVA with Tukey’s post analysis. Differences were considered significant when P ≤ 0.05. All data are represented as mean ± SEM. Source data are provided as a Source Data file.

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