Fig. 4: FMD alleviates cardiac fibrosis, necrosis and hypertrophy in C57/j mice bearing B16-F10 melanoma tumor. | Nature Communications

Fig. 4: FMD alleviates cardiac fibrosis, necrosis and hypertrophy in C57/j mice bearing B16-F10 melanoma tumor.

From: Fasting mimicking diet in mice delays cancer growth and reduces immunotherapy-associated cardiovascular and systemic side effects

Fig. 4

A H&E staining in the heart of C57/J mice bearing B16-F10 melanoma tumor and treated with IgG or anti-OX40/anti-PD-L1 or anti-PD-1/anti-CTLA-4. B Quantification of heart fibrosis and necrosis in the different experimental group (3 tissue sections for each tumor; 5 tumors per each group). C Quantification of pro collagen 1α1 and MMP9 in the heart belonging to different experimental group (n = 5). Statistical analysis was performed using one-way analysis of variance (ANOVA). Differences were considered significant when P < 0.05. All data are represented as mean ± SEM. Source data are provided as a Source Data file.

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