Fig. 2: Dietary fatty acid composition influences adiposity, steatosis, fecal lipid abundance and hepatic gene expression in mice. | Nature Communications

Fig. 2: Dietary fatty acid composition influences adiposity, steatosis, fecal lipid abundance and hepatic gene expression in mice.

From: The interplay between dietary fatty acids and gut microbiota influences host metabolism and hepatic steatosis

Fig. 2

Eight groups of mice were fed high-fat diets with different lipid compositions (MF, A–G) for 9 weeks. a Fat sources and b fatty acid composition of diets. c Body weight, d fecal concentration of free fatty acids, e liver triglyceride concentration, f hematoxylin and eosin staining of liver tissue (scale bar = 100 µm) and g steatosis score. Hepatic expression of h Hmgcs and i Fasn determined by microarray analysis. j Sparse partial least squares regression (sPLS) analysis of microarray data and liver triglyceride levels liver triglyceride concentration. c, g–j: n = 10 except for F where n = 9; d: n = 7 (MF), 6 (A), 7 (B), 7 (C), 4 (D), 5 (E), 6 (F), and 7 (G); e: n = 10 except for B and F where n = 9. Significant p values vs MF diet as determined by two-sided Kruskal–Wallis test are displayed in (d–i). Data are presented as mean ± SEM. SFA saturated fatty acids, MUFA mono-unsaturated fatty acids, PUFA poly-unsaturated fatty acids, Hmgcs1 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1, Fasn fatty acid synthase. See also Supplementary Figs. 2 and 3 and Supplementary Table 1. Source data are provided as a Source data file.

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