Fig. 8: Top 25 most representative canonical pathways modulated by E07 mAb in the mouse model of HOCl-induced SSc and in C3 SSc patients. | Nature Communications

Fig. 8: Top 25 most representative canonical pathways modulated by E07 mAb in the mouse model of HOCl-induced SSc and in C3 SSc patients.

From: Antibody-mediated neutralization of galectin-3 as a strategy for the treatment of systemic sclerosis

Fig. 8

Horizontal bars represent z-score values for each canonical pathway (below 0, inhibited, above 0, activated) for each condition. Red, HOCl-induced mice versus untreated control mice; Blue, HOCl-induced mice versus HOCl-induced mice treated with E07 mAb; Orange, systemic sclerosis patients, cluster 3 versus healthy volunteers of the PRECISESADS cohort.

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