Fig. 2: Genome-wide classification of all protein-coding genes in human cancer cell lines. | Nature Communications

Fig. 2: Genome-wide classification of all protein-coding genes in human cancer cell lines.

From: Systematic transcriptional analysis of human cell lines for gene expression landscape and tumor representation

Fig. 2

a Comparison of the distribution of gene expression in the CCLE 2019 and HPA cell lines (version 21). b Venn diagram showing the overlap between 5,366 genes (5,365 with gene symbols) detected in all 1,019 cell lines in CCLE 2019 and the 1,912 essential genes based on CRISPR gene screening results. c GSOA (hypergeometric testing) of the 1,614 overlapped genes and the 3,751 CCLE-specific genes in (b). P-values were adjusted based on the Benjamini-Hochberg procedure. Ten highly significant GO terms are selectively shown. d Alluvial diagrams showing the number of genes of respective specificity categories for CLDs vs. TCGA cohorts. e (Left) Hierarchical clustering of the 27 CLDs based on the correlation of averaged expression profiles of cell lines for the same cancer type. (Right) Bar plot showing the number of elevated genes in each cell line cancer type. Source data are provided as a Source Data file.

Back to article page