Fig. 4: Prioritizing cancer cell lines as models for human cancer. | Nature Communications

Fig. 4: Prioritizing cancer cell lines as models for human cancer.

From: Systematic transcriptional analysis of human cell lines for gene expression landscape and tumor representation

Fig. 4

For each TCGA cohort, the top five highest-ranked cell lines for the same cancer type were prioritized based on the integration of correlation-based rank (y-axis) and GSEA-based rank (x-axis; NES normalized enrichment score). Names of the selected cell lines are shown (top-5 including tied for fifth for each cohort), with these cell lines in the dot plot highlighted in red. The correlation between the testis cancer cell line SuSa and the TCGA testis cancer cohort TGCT is 0.77, with an NES of 1.97 (adj. P-value = 9.37E-81) for the TCGA testis cohort elevated genes in the SuSa cell line (data not shown in this figure, see Supplementary Data 5). Source data are provided as a Source Data file.

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