Table 1 Categories used for cell line gene expression specificity and distribution

	Category	Description
Specificity	Enriched	A single CLD (cell line gene expression averaged by disease) has 4 times higher expression than any other CLD
	Group enriched	2-10 CLDs have 4 times higher expression than any other CLD
	Enhanced	One or more CLDs have 4 times higher expression than the average of all other CLDs
	Low specificity	The gene does not belong to any of the above categories and is detected above cut-off (nTPM = 1) in at least one CLD
	Not detected	All CLDs have an expression value less than 1
Distribution	Detected in single	Detected in a single cell line above cut-off (nTPM = 1)
	Detected in some	Detected in more than one but less than one third of the cell lines
	Detected in many	Detected in at least a third but not all cell lines
	Detected in all	Detected above cut-off (nTPM = 1) in all cell lines
	Not detected	All cell lines have an expression value less than 1

For gene expression specificity, gene expression in cell lines was averaged by cancer types.

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