Fig. 1: GPR84-Gi signaling facilitates cancer cell phagocytosis.
From: Pro-phagocytic function and structural basis of GPR84 signaling
a Dose-dependent pro-phagocytic effect of 6-OAU. b GLPG1205 and pertussis toxin (PTX) abolished the pro-phagocytic effect of 6-OAU. BH means B6H12, the CD47-blocking antibody. PTX means pertussis toxin. c Knockdown of GPR84 expression in macrophages abolished the pro-phagocytic effect of 6-OAU. Each column represents means ± S.D. (n = 3) Data are representative of at least two independent experiments. Dunnett’s one-way ANOVA test was performed to compare the means of two data groups. *p < 0.1, **p < 0.01, ***p < 0.001 (p1 = 0.0262, p2 = 0.0012, p3 = 0.0017, p4 = 0.0017, p5 = 0.0278, p6 = 0.0011, p7 = 0.0108, p8 = 0.0158, p9 = 0.000025, p10 = 0.000006). ns means no significant difference between the groups.
