Fig. 1: PLCDs of similar albeit non-identical compositions are prevalent in distinct biomolecular condensates. | Nature Communications

Fig. 1: PLCDs of similar albeit non-identical compositions are prevalent in distinct biomolecular condensates.

From: Phase separation of protein mixtures is driven by the interplay of homotypic and heterotypic interactions

Fig. 1

a Average compositional profile of 89 PLCDs found within cellular condensates in Homo sapiens. Here, “Polar” includes Gly, Ser, Thr, Asn, Gln, and Cys. “Aromatic” includes Phe, Tyr, Trp, and His. “Hydrophobic” includes Leu, Iso, Val, and Met. “Charged” includes Asp, Glu, Arg, and Lys. b Distribution of PLCDs across cellular condensates in Homo sapiens. The condensates examined here have at least 40 known protein components. c Length distribution of all 89 distinct PLCDs in a and b. d Compositional profiles of PLCDs within human versions of hnRNPA1 and FUS. For the hnRNPA1 PLCD, the “Other” category includes 2.2% Ala, 1.5% Met, and 1.5% Pro. For the FUS PLCD, the “Other” category includes 1.9% Ala, 1.0% Met, and 5.1% Pro. Source data are provided as a Source Data file.

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