Fig. 7: Simulated mixtures of PLCDs display complex interfacial features and internal organizations. | Nature Communications

Fig. 7: Simulated mixtures of PLCDs display complex interfacial features and internal organizations.

From: Phase separation of protein mixtures is driven by the interplay of homotypic and heterotypic interactions

Fig. 7

a Radial density plots of simulated FUS-LCD and A1-LCD in a 1:1 mixture. Solid black curves indicate logistic fits to each radial density profile. b Radius of gyration normalized by \(\sqrt{N}\), where N is the chain length, as a function of the distance from the condensate center-of-mass. c Values of Li-j (see text) as a function of simulation temperature for a 1:1 mass concentration mixture of FUS-LCD and A1-LCD. In a and b, simulations were performed at a simulation temperature of 49, and translucent rectangles indicate the interfacial regions predicted by the corresponding logistic fit of FUS-LCD (red) and A1-LCD (blue). n = 10 independent simulations with random starting seeds. Error bars in all panels are standard errors about the mean. Source data are provided as a Source Data file.

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