Fig. 8: Internal condensate organizations of polymer mixtures depend on the interplay of homotypic vs. heterotypic interactions. | Nature Communications

Fig. 8: Internal condensate organizations of polymer mixtures depend on the interplay of homotypic vs. heterotypic interactions.

From: Phase separation of protein mixtures is driven by the interplay of homotypic and heterotypic interactions

Fig. 8

a–d Relative interaction energies (left column), values of Li-j (see text) as a function of simulation temperature (central column), and a schematic depicting the predicted condensate organization (right column) for 1:1 mixtures of polymers A and B with various interaction matrices. a Homotypic and heterotypic interactions are all equivalent and set to −3.3 in LaSSI. b Heterotypic interactions are stronger than homotypic interactions. Heterotypic interactions are set to −3.6 and homotypic interactions to −3.0. c Homotypic interactions are stronger than heterotypic interactions. Homotypic interactions are set to −3.6 and heterotypic interactions to −3.0. d Homotypic A-A interactions are weaker than homotypic B-B interactions and heterotypic A-B interactions, which are equivalent. Homotypic A-A interactions are set to −3.0 and all other interactions are set to −3.6. n = 5 independent simulations with random starting seeds. Error bars for the values of Li-j are standard errors about the mean, though they are typically smaller than the marker size. Source data are provided as a Source Data file.

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