Fig. 4: Cell-cell communication of gills between freshwater and terrestrialized condition.

a Comparison of cell-cell communications between cell types in terrestrialized lungfish gill (left) and freshwater lungfish gill (right) by heatmap. Color means the log-normalized numbers of CellPhoneDB ligand-receptor pairs (LR pairs) b Enriched biological processes of LR pairs in the lungfish gill. The enrichment analysis was generated via the Enrichr web server using Fisher exact test, and the Benjamini-Hochberg (BH) was used for correction for multiple hypotheses testing. P values are indicated on the x-axis. c The expression of selected LR pairs in gill cell types of freshwater (FW) and terrestrialized (AE) lungfish. Annotated as in Fig. 2h. Source data are provided as a Source Data file.