Fig. 5: Observed and predicted probability of positive IgA responses against RBD after the first dose of the BNT162b2 vaccine. | Nature Communications

Fig. 5: Observed and predicted probability of positive IgA responses against RBD after the first dose of the BNT162b2 vaccine.

From: Previous immunity shapes immune responses to SARS-CoV-2 booster vaccination and Omicron breakthrough infection risk

Fig. 5

Distribution of positive IgA response (probability) over time (days from the first vaccine) in infection-naive individuals (left), in individuals previously infected with a variant before Omicron (middle), and in individuals infected with Omicron (right). Blue and pink backgrounds represent the conditional density estimation of positive and negative IgA responses, respectively. Solid and dashed lines represent the predicted probability of positive IgA responses calculated by the model in females and males, respectively. Black, yellow, and blue colors represent individuals with age <40, 40–60, and >60 years, respectively. Vertical dashed and dashed-dotted lines represent when the second and the third dose was administered, respectively (median days). Shadowed areas represent the 95% confidence interval. Centre for the confidence interval is the predicted (mean) values. Predictive values in the gray-shaded area (days 250–350) do not represent a realistic projection due to insufficient observed data to provide realistic predictive data. Source data are provided as a Source Data file.

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