Fig. 6: Protective efficacy in vaccinated guinea pigs. | Nature Communications

Fig. 6: Protective efficacy in vaccinated guinea pigs.

From: A Lassa virus mRNA vaccine confers protection but does not require neutralizing antibody in a guinea pig model of infection

Fig. 6

A Disease score. B Weight change. Dashed line represents 20% weight loss (animal at 80% of the original weight) which was the weight cutoff for euthanasia. C Body temperature, D Viremia. Lower limit of detection is 50 PFU/mL. Only the control group is included, as no viremia was detected in either vaccinated groups. For (B–D), error bars represent the standard deviation between the averages of the 5 animals per group. E Percent survival. Mean values based on 5 animals per group ± SD. P = 0.0014 for both WT GPC vaccine versus control and prefusion GPC vaccine versus control. Log-rank (Mantel-Cox) test. For all figures, WT GPC vaccinated animals represented by a filled-in black circle. Prefusion GPC vaccinated animals represented by a filled-in green triangle. All non-vaccinated control animals represented but a filled-in purple diamond. For all figures, each group is an average of the N = 5 animals per group. Source data are provided as a Source Data file.

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