Fig. 7: Histopathology and LASV immunohistochemistry in organs of vaccinated and control animals. | Nature Communications

Fig. 7: Histopathology and LASV immunohistochemistry in organs of vaccinated and control animals.

From: A Lassa virus mRNA vaccine confers protection but does not require neutralizing antibody in a guinea pig model of infection

Fig. 7

Images of H&E stained (A–I) and LASV nucleoprotein immunostained (J–R) tissues of guinea pig lung (A–C and J–L), spleen (D, E and M–O) and liver (G–I and P–R). Scale bars in bottom right corners of H&E images = 103 μM. IHC images magnified at 20x, scale bars added in ImageJ in bottom right corners = 72 μM. C The box indicates a representative area of viral interstitial pneumonia. D, E The arrows indicate germinal center activation, which is notably more robust in vaccinated animals compared to the unvaccinated control. I The arrow shows an area demonstrating steatosis in the liver of the control animal, which is not present in the vaccinated animals. Staining was performed once on duplicate slices of tissue.

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