Fig. 2: Outward-open structure of PHT1 in complex with Sb27. | Nature Communications

Fig. 2: Outward-open structure of PHT1 in complex with Sb27.

From: Molecular basis of TASL recruitment by the peptide/histidine transporter 1, PHT1

Fig. 2

a Cryo-EM map and b cartoon representation of PHT1 in complex with Sb27. The structure represents the outward-open conformation of PHT1 in complex with two molecules of Sb27 (gray). Sb27a binds at the bundle bridge of PHT1 (yellow) which links the N-domain (blue) with the C-domain (pink) of PHT1, while Sb27b binds at the N-domain of PHT1. c View of PHT1 from the luminal side, showing a cavity open to the lysosome lumen, while d view from the cytosol side illustrates that the cavity is closed and held in place by several highlighted interactions between the N- and C- domains.

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