Fig. 1: Establishment of PROCR+/ZEB1+/PDGFRα+ (PZP) cell lines from the Normal-Healthy breast tissues of women of African ancestry. | Nature Communications

Fig. 1: Establishment of PROCR+/ZEB1+/PDGFRα+ (PZP) cell lines from the Normal-Healthy breast tissues of women of African ancestry.

From: Stromal heterogeneity may explain increased incidence of metaplastic breast cancer in women of African descent

Fig. 1

a Genetic ancestry mapping of breast tissue donors (KTB40, KTB42, KTB32, KTB53, KTB57, and KTB59) using a panel of 41-SNP. b PROCR+/EpCAM‒ cells are enriched in established cell lines from women of African ancestry (n = 3). Isotype controls are shown in Fig. S1d. c Quantitation of PROCR+/EpCAM‒ cells (n = 3). d ZEB1 expression levels in various PROCR+/EpCAM‒ cell lines compared to EpCAM+ (KTB34 and KTB39) luminal cell lines (n = 3). KTB40*p < 0.0001, KTB42*p = 0.0002, KTB32*p < 0.0001, KTB53*p < 0.0001, KTB57*p < 0.0001, KTB59*p = 0.0003. e PROCR+/ZEB1+ cell lines express PDGFRα as determined by flow cytometry (n = 3). f Quantitation of PDGFRα+ cells (n = 3). ***p < 0.001, ****p < 0.0001 by one-way ANOVA. All the data points are shown as mean ± SEM. Source data are provided as a Source Data file.

Back to article page