Fig. 4: Azole susceptibility and PDR1 and CDR1 expression data for C. glabrata strains from patient L. | Nature Communications

Fig. 4: Azole susceptibility and PDR1 and CDR1 expression data for C. glabrata strains from patient L.

From: Genotypic diversity and unrecognized antifungal resistance among populations of Candida glabrata from positive blood cultures

Fig. 4

Strains L4 and L8 were more resistant to all 4 azole agents tested than were the other 8 L strains. Y-axis represents fold difference of PDR1 or CDR1 expression by respective L strains relative to the index strain L1, normalized to 18 S rRNA. Data on graph are presented as mean ± standard error of mean (SEM) of relative gene expression of PDR1 or CDR1 from quadruple experiments. Statistical analyses were performed using one-way ANOVA with Dunnett’s multiple comparisons test comparing the mean rank of relative gene expression of L1 to other L strains. By RT-PCR, relative expression of PDR1 by strain L4 was significantly higher than that by strain L1 (mean rank difference of 1.3 (95% confidence interval (CI) of difference: 0.9 to 1.6), p < 0.0001). Relative expressions of CDR1 by strains L4 and L8 were significantly higher than that by strain L1 (L4 vs L1: mean rank difference of 20.2, 95% CI: 19.1 to 21.3, p < 0.0001; L8 vs L1: mean rank difference of 10.8, 95% CI: 9.7 to11.9, p < 0.0001). * denotes that the difference is statistically significant (p < 0.0001).

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