Fig. 7: Tissue burdens of C. glabrata strains J1 and J9 in kidneys, spleens and livers of mice during hematogenously disseminated infections.
Sixteen mice per group (8 male, 8 female) were infected intravenously (IV) with 1×107 CFU of respective strains (J1, empty circle; J9 inverse triangle), and they were sacrificed for CFU enumeration at days 1, 3 and 7. Log10 tissue burdens per organ are presented in scatter dot plots below; red lines represent mean of log (CFU/gram of tissue) ± standard error of mean. Strain J9 was significantly attenuated for virulence in all target organs. P-values (two-tailed) for pair-wise comparison were determined using student’s t tests with Welch’s correction. For kidney tissue burdens, Welch-corrected t and degree of freedom were 11.34 and 27.63 at day 1, respectively; 11.14 and 23.25 at day 3, and 6.56 and 25.02 at day 7, respectively. Corresponding data for spleens were 7.25 and 29.24 at day 1, 14.92 and 27.55 at day 3 and 28.06 and 24.08 at day 7; corresponding liver data were 1.15 and 25.0 at day 1, 11.01 and 29.65 at day 3, and 6.32 and 15 at day 7. Overall, there were no significant differences in tissue burdens between male and female mice.
