Fig. 3: Molecular alteration landscape of IDH wild-type glioma.

a The spectrum of somatic genetic alterations occurring in multiregional samples (n = 255) from IDH wild-type glioma patients (n = 48) indicated the frequency of truncal, shared, and private events within each single patient (left bars), within all patients (right bar, Total), and within contrast-enhancing and contrast non-enhancing samples (right bars, CE, and NE, respectively). The proportion of mutation types was significantly different between CE and NE (two-sided Fisher’s exact test p = 4.85e−43). Source data are provided as a Source data file. b Somatic genetic mutations and copy number alterations occurring in IDH wild-type glioma (260 samples from 53 patients). Samples are grouped by patients. Mutation load and tumor purity are reported in the top barplot and heatmap track, respectively. Clinical annotation and gene expression classification are indicated in the bottom tracks. Gene alteration frequency in patient cohort is indicated as percentage on the left.