Fig. 6: Molecular tumor evolution in IDH wild-type glioma. | Nature Communications

Fig. 6: Molecular tumor evolution in IDH wild-type glioma.

From: Integrated molecular and multiparametric MRI mapping of high-grade glioma identifies regional biologic signatures

Fig. 6

a Alterations exclusive to the NE region are displayed from a subset of IDH wild-type patients. Alterations specific to the NE region were annotated with gene ontology terms and grouped based on ontology similarity. b Evolutionary trajectories of genetic alterations have been predicted by comparing the multiregional molecular profiles in a subset of IDH wild-type glioma patients (n = 34) with more than one truncal driver event identified. Four evolutionary models of IDH wild-type glioma have been proposed from the supervised clustering of repeated initiating trajectories. The number of trajectories observed within each cluster is reported (light green boxes); the number of clonal (red) and subclonal (blue) events is indicated for each alteration.

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