Fig. 6: Validating the functional selectivity of a new ITC subregion.
From: High-dimensional topographic organization of visual features in the primate temporal lobe
a, b Four functional networks reported in a previous paper18 were localized in the temporal lobe of one monkey, shown as contour plots (STA and SPA: p < 10−4; STI and SPI: p < 10−6; Student’s t-test, two-tailed, not corrected for multiple comparisons; the color code is shown in the inset) overlaid on the map of the animacy feature (a). Preferred (positive) and nonpreferred (negative) images were selected for subregions within the peri-STS region left out by the four networks (b). Note that the original ImageNet images are replaced with natural images from Pixabay (https://pixabay.com/). A separate experiment comparing positive to negative images revealed new subregions in the peri-STS region (white outlines in a, p < 0.001). Dashed lines indicate the STS fundus. The locations of main sulci are shown above (LS: lateral sulcus; OTS: occipitotemporal sulcus). c In two monkeys, t-contrasts between the two conditions were negatively correlated with projections of 25D features onto “animacy” feature within the peri-STS region, and positively correlated with the projections onto the feature dimension used to select the images. CI: 1% confidence interval. d A coronal slice showing the location of a positive-block preferred region in M3 targeted for electrophysiology. Scale bar indicates the common logarithm of the probability of error. e Responses of an example neuron to images in positive and negative blocks of the fMRI experiment (see Methods). Shadings represent SEM. f, g Same as (d, e), but for a negative-block preferred region. h Average time courses of t-contrasts between the two conditions, with purple and green lines indicating positive- and negative-block preferred regions, respectively (n = 86 and 56 cells). Shadings represent SEM. Top lines indicate significant time windows (p < 0.01, Student’s t-test, two-tailed, see text). i PCA was performed on the 25D preferred features of all neurons recorded in two areas, estimated using the 25-IC stimulus set. The distributions of PC1 scores are shown above. j An example neuron’s responses to the synthesized images of the same feature in (b) (Fig. S4g). k Average time courses of t-contrasts between positive and negative conditions for the synthesized images (brown) and those between positive conditions for the synthesized and natural images (black). Same convention as (h). n = 34 cells. Source data are provided as a Source Data file.
