Fig. 1: Overall structures of cFSP1.
From: Structural insights into FSP1 catalysis and ferroptosis inhibition
a Schematic representations of cFSP1. N-terminal myristoylation motif excluded in crystallized cFSP1 is marked with hatched lines. Lime, blue and orange boxes denote the FBD (residues 12–141 and 241–318), NBD (residues 142–240) and CTD (residues 319–373), respectively. b, c Cartoon representation of cFSP1ΔN in substrate-free form (b) and in complex with CoQ1 (c). Individual cFSP1ΔN domains are colored according to the scheme in (a). FAD and CoQ1 molecules are shown as stick representations. d, e Two views of the structural alignment between cFSP1 (substrate-free form) and NDH-2 from Caldalkalibacillus thermarum (PDB, 4NWZ). The FBD, NBD and CTD of NDH-2 are coloured in marine, yellow and pink, respectively. Domains of cFSP1 are also colored according to the scheme in (a).
