Fig. 7: Conserved Domain and functional analysis of puncta(+) and puncta(-) Training and Verification FOs.

Functional terms identified from the Conserved Domain Database (CDD) are shown for the 115 puncta(+) Training and Verification FOs localized to the nucleus (a), cytoplasm (b), and both compartments (c). Functional terms identified from the Conserved Domain Database (CDD) are shown for the 63 puncta(-) Training and Verification FOs localized to nucleus (d), cytoplasm (e), and both compartments (f). The colors of the bars represent the three major functional classes, regulation of gene expression (including transcription, chromatin, and RNA binding Conserved Domain functional terms; purple), regulation of cell signaling (including protein kinase, protein binding, and cell signaling Conserved Domain functional terms; blue) and other functions (gray). The numbers in each bar indicate the number of unique FOs with the noted functional term, and asterisks indicate statistically significant over-representation based on p-value estimates from 100,000-fold one-sided resampling with replacement using identically-sized protein sets (*p < 0.05; **p < 0.01; ***p < 0.001). All source data are provided as a Source Data File.