Fig. 9: The FO condensate landscape.

a Cytoscape network analysis of all FO parents (nodes) from the Training and Verification FO sets. Edges indicate a fusion event. Solid green edges reflect puncta(+) and dotted red edges puncta(-) cellular condensation behavior, respectively. b Analysis of the condensation behavior of all FO parents from (A) that are involved in ≥ 3 fusion events in our Training and Verification FO sets (degree value ≥ 3). The percent of puncta(+) FOs in which the parent is involved is plotted on the y-axis and the degree value of the parent is on the x-axis. Circles represent FO parents with the same puncta(+) percentage and degree values, and the size of the circle reflects the number of FO parents encompassed by that circle. Numbers following parent names indicate the total patient count for FOs associated with that parent. The parent names are color-coded to indicate the predominant functional associations of the FOs in which each parent is found as analyzed through the Conserved Domain Database (CDD). Purple indicates a predominant association with regulation of gene expression, blue indicates regulation of cell signaling, and gray indicates all other functions. See Supplementary Dataset 7 for all terms. c Analysis of the condensation behavior of all Untested FO parents that are involved in ≥ 3 fusions (degree value ≥ 3). The percentage of puncta(+) FOs in which a parent is involved is plotted on the y-axis and the degree value of the parent is on the x-axis. Circles represent clusters of FO parents with the same puncta(+) percentage and degree values, and the size of a circle reflects the number of FO parents encompassed by that circle. The gradient coloring of circles reflects the dominance of the functional classification of the FOs in which the parents comprising each circle are involved, with 50% indicating that the two functional classes are equally represented. Functional assignment is based on matching FOs to Groups 1–4 of puncta(+) or Group 1′−3′ of puncta(-) FOs. Orange circles indicate that FOs did not match any of the Groups 1–4. Circles containing a single parent are labeled with the parent’s name. Cancer type abbreviations are defined in Supplementary Dataset 3. All source data are provided as a Source Data File.