Fig. 4: b-mosaic particles elicit broad antibody responses. | Nature Communications

Fig. 4: b-mosaic particles elicit broad antibody responses.

From: Nanoparticle display of prefusion coronavirus spike elicits S1-focused cross-reactive antibody response against diverse coronavirus subgenera

Fig. 4

a Groups of 10 female BALB/cJ mice were immunized twice with Ī²-CoV mosaic_I53_dn5, MERS_I53_dn5, SARS-1_I53_dn5, SARS-2_I53_dn5, HKU1_I53_dn5, or OC43_I53_dn5 to compare antibody responses elicited from co-display and monotypic display of each spike. Control mice were immunized with H1_I53_dn5. Mice were bled at week 5 for serology. bā€“h Sera were screened by ELISA for IgG binding to each strain. Boxes and horizontal bars denote the IQR and medians, respectively. Whisker endpoints are equal to the minimum and maximum values. Circles denote each individual animal. Immune profiling in BALB/cJ performed once.

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