Table 1 Baseline characteristics by bivalent vaccine type

From: Omicron variant neutralizing antibodies following BNT162b2 BA.4/5 versus mRNA-1273 BA.1 bivalent vaccination in patients with end-stage kidney disease

 

No. (%)

Characteristic

Total (n = 98)

mRNA-1273 (BA.1) (n = 72)

BNT162b2 (BA.4/BA.5) (n = 26)

Demographics

Age, median (IQR), y

70 (61, 77)

69 (61, 75)

70 (62, 78)

Sex (Female)

34 (35)

21 (29)

13 (50)

Race

   

     Asian

26 (27)

20 (28)

6 (23)

     Black

7 (7)

6 (8)

1 (4)

     Caucasian

38 (39)

33 (46)

5 (19)

     Other/unknown

27 (28)

13 (18)

14 (54)

Patient type

   

     Dialysis

83 (85)

57 (79)

26 (100)

     Kidney transplant

15 (15)

15 (21)

0 (0)

Cause of chronic kidney disease

   

     Diabetes

29 (30)

22 (31)

7 (27)

     Glomerulonephritis

21 (21)

13 (18)

8 (31)

     Hypertension

15 (15)

11 (15)

4 (15)

     Other

33 (33)

26 (36)

7 (27)

Prior COVID-19 (RT-PCR or rapid antigen test)

25 (26)

19 (26)

6 (23)

Vaccine Type

Dose 1

   

     ChAdOx1

3 (3.1)

2 (2.8)

1 (3.8)

     mRNA-1273

36 (37)

35 (49)

1 (3.8)

     BNT162b2

59 (60)

35 (49)

24 (92)

Dose 2

   

     ChAdOx1

3 (3.1)

2 (2.8)

1 (3.8)

     mRNA-1273

40 (41)

39 (54)

1 (3.8)

     BNT162b2

55 (56)

31 (43)

24 (92)

Dose 3

   

     mRNA-1273

56 (57)

45 (62)

11 (42)

     BNT162b2

42 (43)

27 (38)

15 (58)

Dose 4

   

     mRNA-1273

65 (66)

56 (78)

9 (35)

     BNT162b2

26 (27)

10 (14)

16 (62)

     mRNA-1273 Bivalent (BA.1)

6 (6.1)

6 (8.3)

0 (0)

     BNT162b2 Bivalent (BA.4/BA.5)

1 (1.0)

0 (0)

1 (3.8)

Dose 5

   

     mRNA-1273 Bivalent (BA.1)

66 (73)

66 (100)

0 (0)

     BNT162b2 Bivalent (BA.4/BA.5)

24 (27)

0 (0)

24 (100)

Bivalent vaccine dose number

     Dose 4

8 (8.2)

3 (4.1)

5 (20)

     Dose 5

90 (92)

70 (96)

20 (80)

Comorbidities

     Chronic obstructive pulmonary disease

8 (8.2)

5 (6.9)

3 (12)

     Coronary artery disease

14 (14)

7 (9.7)

7 (27)

     Congestive heart failure

15 (15)

10 (14)

5 (19)

     Cerebrovascular disease

10 (10)

7 (9.7)

3 (12)

     Hypertension

80 (82)

55 (76)

25 (96)

     Malignancy

9 (9.7)

7 (9.7)

2 (9.5)

     Peripheral vascular disease

8 (8.2)

6 (8.3)

2 (7.7)

Immunosuppression

17 (17)

16 (22)

1 (3.8)

     Prednisone

16 (16)

15 (94)

1 (100)

     Mycophenolic acid

12 (12)

12 (75)

0 (0)

     Calcineurin inhibitor

16 (16)

16 (100)

0 (0)