Fig. 2: Regional variations in structure-function coupling: atlas-based analysis.
A Mean differences in structure-function coupling across the 7 resting-state functional systems (generated using the 100 unrelated HCP subjects and Schaefer 400 atlas; n = 400 brain regions/datapoints). Data are presented as boxplots (median value at center line, lower quartile at left bound, upper quartile at right bound) with whiskers extending towards the minimum and maximum non-outlier values of the data; single datapoints denote outliers. The brain regions in each functional system are overlayed on the standardized fsaverage brain’s surface and illustrated on the left side. LIM Limbic, VEN Ventral Attention, FP Fronto-Parietal, DMN Default Mode Network, DOR Dorsal Attention, MOT Somatomotor, VIS Visual. B Mean differences in structure-function coupling across the 5 cyto-architectonic classes (generated using the 100 unrelated HCP subjects and Schaefer 400 atlas; n = 400 brain regions/datapoints). Data are presented as boxplots (median value at center line, lower quartile at left bound, upper quartile at right bound) with whiskers extending towards the minimum and maximum non-outlier values of the data; single datapoints denote outliers. The brain regions involved within each class are overlayed on the standardized fsaverage brain’s surface and illustrated on the left side. POL Polar, AGR Agranular, FRO Frontal, PAR Parietal, GRA Granular. C Scatterplot between the principal functional gradient scalar of each brain region and its corresponding structure-function coupling (n = 400 brain regions/datapoints). A linear regression was fit along with a 95% confidence interval (shown in red); the correlation coefficient (two-tailed Spearman’s ρ: r), p-value corresponding to the spatial permutation test (pspin), and histograms corresponding to each variable are reported. D Scatterplot between the “BigBrain” gradient scalar of each brain region and its corresponding structure-function coupling (n = 400 brain regions/datapoints). A linear regression was fit along with a 95% confidence interval (shown in red); the correlation coefficient (two-tailed Spearman’s ρ: r), p-value corresponding to the spatial permutation test (pspin), and histograms corresponding to each variable are reported. Source data are provided as a Source Data file.
