Fig. 5: Plasma exposure of thioamidated and N-methylated macrocyclic peptides post oral administration. | Nature Communications

Fig. 5: Plasma exposure of thioamidated and N-methylated macrocyclic peptides post oral administration.

From: An amide to thioamide substitution improves the permeability and bioavailability of macrocyclic peptides

Fig. 5

a Plasma concentration vs time plot of 10, 10a, 10e, and 10f after a single dose oral administration (10 mg/Kg) in male Wistar rats. n = 3 ± SEM. b Comparison of the plasma concentration with respect to time of the macrocycles obtained by thioamidation and N-methylation of amide bonds 1 A (10a, 10h) and 5 A (10e, 10k), following a single dose oral administration (10 mg/Kg) in male Wistar rats. n = 3 ± SEM. Each bar represents mean values of three biological replicates: dots are individual data points. Source data are provided as a Source Data file.

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