Fig. 5: THEMIS performance for multicancer detection. | Nature Communications

Fig. 5: THEMIS performance for multicancer detection.

From: Multimodal analysis of cell-free DNA whole-methylome sequencing for cancer detection and localization

Fig. 5

a Receiver operator characteristics for the classification of cancer patients from healthy controls by THEMIS in the training (healthy n = 352; cancer n = 542) and the test (healthy n = 145; cancer n = 238) cohort split by cancer type. The 95% confidence intervals (CIs) for AUCs are calculated with 2000 stratified bootstrap replicates. b Detection sensitivity of individual cancer types by clinical stage. Sensitivity at a specificity of 99% is depicted with bar charts. Error bars represent 95% Wilson confidence intervals. The numbers of samples in the training and the test cohort for each stage are indicated below the plots and separated by a vertical line. Cancer samples with unknown stages are omitted from display. Source data are provided as a Source Data file.

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