Fig. 4: Structural basis of SFTSV peplomer assembly.
From: Cryo-EM structure of severe fever with thrombocytopenia syndrome virus
a Structure of the hexon peplomer (depicted with hexon C structure). For clarity of visualizing inter-heterodimer interactions, two adjacent Gn/Gc heterodimers are colored by domains or subunits, with the other subunits colored in white and set to transparent. b Top view of the hexon to visualize the interactions in the crown region. Domain B of each subunit is shown in cartoons to reveal its interactions with adjacent subunits. c Zoom-in view of the interactions between Gn domain B and the domain A from an adjacent subunit. d Bottom view of the IM helix network in hexons. e The interface between two adjacent Gn/Gc heterodimers. The Gn subunit is shown in cartoons and Gc subunits in surface models, colored by domains. The fusion loops are highlighted in green. f Close-up view of the molecular context shielding the Gc fusion loops. The fusion loops are sandwiched by the Gn domain B and a neighboring Gc subunit. g Complementary electrostatic interactions between Gn α4 helix and Gc domain I from the neighboring heterodimer. The key hydrogen bonds and salt bridges are shown as dashed lines. h–i Structure of the penton peplomer in side h and top i views, shown in a similar manner as the hexon in a, b. j Comparison of the relative orientations between two adjacent Gn/Gc heterodimers in pentons and hexons.
