Fig. 9: Deficiency in Blautia-produced acetate underlies breast cancer progression promoted by chronic stress. | Nature Communications

Fig. 9: Deficiency in Blautia-produced acetate underlies breast cancer progression promoted by chronic stress.

From: Repressed Blautia-acetate immunological axis underlies breast cancer progression promoted by chronic stress

Fig. 9

In the present study, using an effective approach that combined temporospatial mapping of gut microbiota and its metabolites with metabolomics and metagenomics, we reveal that chronic stress results in reduced numbers of the causal microbe (Blautia) and its metabolite (acetate). These deficiencies may underlie chronic stress-promoting breast cancer progression by regulating the reduction of the number and function of CD8+ T cells in the tumor microenvironment. This figure presents a schematic representation of the proposed mechanism, illustrating the role of Blautia-produced acetate in regulating CD8+ T cells and ultimately impacting tumor growth in the conditions of co-occurrence of depression and breast cancer. Created with BioRender.com.

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