Table 2 AUC estimates (95% confidence interval) for European-centric PRS, known loci PRS, PRS-CSx and LDPred2

From: Combining Asian and European genome-wide association studies of colorectal cancer improves risk prediction across racial and ethnic populations

Race and Ethnicity

Cases/ controls

European-centric PRS

Known Loci PRS

PRS-CSx

LDPred2

Asian

2420/9605

0.59 (0.57–0.60)

0.60 (0.59-0.62)

p-val*: 0.24

0.64(0.58–0.69)

p-val*: 0.06

p-val+: 0.32

0.63 (0.62–0.64)

p-val*: 4.5e−9

p-val+: 1.6e−6

p-val**: 0.75

Black or African American

1954/11,869

0.58 (0.56–0.59)

0.58 (0.56–0.59)

p-val*: 0.92

 

0.59 (0.57–0.61)

p-val*: 0.05

p-val+: 0.01

Latinx or Hispanic

1681/8696

0.59 (0.57–0.61)

0.59 (0.57–0.60)

p-val*: 0.76

0.62 (0.60–0.63)

p-val*: 5.0e−3

p-val+: 1.0e−3

Non-Hispanic White

3651/115,105

0.63 (0.62–0.65)

0.61 (0.60–0.62)

p-val*: 9.0e−4

0.64 (0.62-0.65)

p-val*: 0.15

p-val+: 1.8e−5

0.65 (0.64–0.66)

p-val*: 6.0e−3

p-val+: 1.1e–14

p-val**: 3.0e−3

  1. The p-values are two-sided and calculated based on 500 bootstrapping samples.
  2. *p-value comparison of PRS with the European-centric PRS.
  3. +p-value comparison of PRS with the known-loci PRS.
  4. **p-value comparison of PRS with the PRS-CSx.
  5. **All AUC estimates were adjusted for age, sex, and top 4 principal components.
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