Fig. 6: Stereoselectivity of MonCI.
From: Triepoxide formation by a flavin-dependent monooxygenase in monensin biosynthesis
a The fused substrate- and FAD-binding pocket of MonCI and the predicted structure of the bound C(4a)-(hydro)peroxyflavin adenine dinucleotide. b Six models of the MonCI–premonensin A complex. Premonensin A was manually built inside the MonCI pocket in the conformation required to produce each of the six stereoisomers. Red circles indicate regions of steric clash between MonCI and premonensin A.
