Table 1 Colocalization analyses of COVID-19 outcomes and other diseases at the identified sQTL loci
From: Alternative splicing in lung influences COVID-19 severity and respiratory diseases
sQTL locus (rsID) | chr | pos (b38) | EA | NEA | Intron junction | COVID-19 outcome | PP* between sQTL and COVID-19 | Other outcome | PP* between COVID-19 and other outcome |
|---|---|---|---|---|---|---|---|---|---|
ATP11A (rs12585036) | 13 | 112881427 | C | T | chr13:112,875,941-112,880,546 ↑ (lung, WBC) | critical illness ↓ | 1.00 | idiopathic pulmonary fibrosis ↑ [PMID: 31710517] | 1.00 |
DPP9 (rs12610495) | 19 | 4717660 | A | G | chr19:4,714,337-4,717,615 ↑ (lung) | critical illness ↓ | 0.96 | idiopathic pulmonary fibrosis ↓ [PMID: 31710517] | 1.00 |
NPNT (rs34712979) | 4 | 105897896 | G | A | chr4:105,898,001-105,927,336 ↑ (lung) | critical illness ↑ | 1.00 | FEV1/FVC ratio↑ [PMID: 30804560] | 1.00 |
COPD↓ [PMID: 30804561] | - | ||||||||
Asthma↓ [PMID: 31959851] | - | ||||||||
OAS1 (rs10774671) | 12 | 112919388 | G | A | chr12:112,917,700-112,919,389 ↑ (lung) | critical illness ↓ | 0.99 | systemic lupus erythematosus ↓ [PMID: 33272962] | - |
chronic lymphocytic leukemia↑ [PMID: 28165464] | - | ||||||||
MUC1 (rs4072037) | 1 | 155192276 | C | T | chr1:155,192,310:155,192,786 ↑ (lung) | reported infection ↑ | 0.97 | inflammatory bowel disease ↓ [PMID: 28067908] | 1.00 |
gastric cancer ↓ [PMID: 26098866] | - | ||||||||
gout ↑ [PMID: 33959723] | - | ||||||||
Urate level ↑ [PMID:33462484] | 1.00 | ||||||||
PMF1 (rs1052067) | 1 | 156236330 | A | G | chr1:156,233,728:156,236,349↑ (lung, whole blood) | reported infection ↓ | 0.95 | Testicular germ cell tumor ↑ [PMID: 28604728] | - |
Serum creatinine levels ↓ [PMID: 34594039] | - | ||||||||
Intracerebral hemorrhage ↓ [PMID: 24656865] | - | ||||||||
Ischemic stroke ↓ [PMID: 29531354] | 0.30 |
