Fig. 5: Illustration of the three diversification regimes observed based on automated FC in the function of the switching cost. | Nature Communications

Fig. 5: Illustration of the three diversification regimes observed based on automated FC in the function of the switching cost.

From: Fitness cost associated with cell phenotypic switching drives population diversification dynamics and controllability

Fig. 5

The constrained diversification regime is observed at low switching costs. According to the regime, all cells switch from the OFF state to the ON state according to a relatively homogenous diversification process, and the population exhibits a low H(t) (there is no increase in entropy upon activation of cells. The dispersed and bursty regimes are observed at high switching costs. Accordingly, cells switch from the OFF to the ON state in a quite heterogeneous way. The resulting stochastic switching is hypothesized to play a role in the stabilization of the cell population under continuous cultivation as a way to mitigate the fitness cost associated with switching. Upon diversification, the population exhibits a higher entropy.

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