Fig. 6: Main outputs of the FlowStocKS simulations.

a Evolution of the mean entropy recorded from the H(t) profile in a chemostat in function of the fitness cost (here expression as the percentage of reduction of the initial growth rate prior phenotypic switching). These values are equivalent to the basal entropy shown in Fig. 4. b Evolution of the mean flux of cells recorded during chemostat experiments in the function of the fitness cost associated with phenotypic switching (see Fig. 1 for more details about the computation of the flux of cells). c Selected simulated time scatter fluorescence plots illustrating the different diversification regimes observed at different fitness costs (the whole simulation dataset can be found in Supplementary Movie 4). d Selected simulated time scatter fluorescence plots illustrating the progressive transition between the dispersed and constrained diversification regimes. e Selected simulated time evolution for the fluxes of cells recorded for different values of fitness cost. The bursty regime is characterized by the spontaneous generation of flux of cells (bursts) in chemostat cultivations. f Reduction of the entropy upon environmental forcing in the function of the fitness cost associated with phenotypic switching. The entropy values have been computed by subtracting the mean entropy value recorded for the chemostat experiment from the corresponding ones obtained in Segregostat and are equivalent to the controllability shown in Fig. 4.