Fig. 5: NTDs of BTR1 in the inward-facing conformation.
From: Structural insights into the conformational changes of BTR1/SLC4A11 in complex with PIP2
a, b Structural comparison of BTR1OF/APO (blue) and BTR1IF/R125H (gray) monomers aligned by their TMDs viewed from the side (a) and the bottom (b). The rotation angle and centroid shift between BTR1OF/APO and BTR1IF/R125H are marked with dotted lines. c Structural comparison of BTR1OF/APO (blue) and BTR1IF/R125H (gray) aligned by their NTDs. The TMDs are both shown in transparent mode. d Hydrophobic interactions and hydrogen bonds formed between the NTD and TMD of one BTR1IF/R125H monomer. The NTD, gate domain and core domain of one BTR1IF/R125H monomer are colored in pink, blue and green, respectively. The interactions are shown as dotted lines. e Close-up view of the hydrophobic interactions between the NTD and gate domain of one BTR1IF/R125H monomer. The hydrophobic interaction between V205 and Y820 is shown as dotted lines. f Hydrogen bonds between the gate domain of one BTR1IF/R125H monomer and the NTD of the other monomer. The interactions are shown as dotted lines.
