Fig. 6: BTR1 state transition process.
From: Structural insights into the conformational changes of BTR1/SLC4A11 in complex with PIP2
a BTR1 is in the outward-facing state with PIP2 stably binding. b Dissociation of PIP2 molecules from the NTDs of BTR1 after ions reach the substrate binding sites induces the rotation of the core domains, leading to the occluded state of BTR1. c Disruption of the interaction between PIP2 and BTR1 due to acidic pathological condition or pathogenic mutation in the L site, triggers the flip of the NTD and the conformational change into the inward-facing state.
