Fig. 2: Modelling of the metabolic BMI score and comparison of the captured lipid biology with BMI in the AusDiab cohort (n = 10,339 independent samples). | Nature Communications

Fig. 2: Modelling of the metabolic BMI score and comparison of the captured lipid biology with BMI in the AusDiab cohort (n = 10,339 independent samples).

From: Metabolic phenotyping of BMI to characterize cardiometabolic risk: evidence from large population-based cohorts

Fig. 2

a Correlation between measured BMI and predicted BMI (orange scatter plot). The blue and sky-blue histogram depicts the distribution of BMI and predicted BMI respectively. b Correlation between measured BMI and metabolic BMI (mBMI) (green scatterplot). The blue and green histogram depicts the distribution of BMI and metabolic BMI respectively. c Associations of BMI (as a predictor) with plasma lipid species (as outcome, n = 575 species) and (d) association of mBMIΔ with plasma lipid species using linear regression analysis adjusting for age and sex. Two-sided p values for each lipid species with grey open circles (p > 0.05), grey and dark closed circles (p < 0.05) are presented after correction for multiple comparisons using the method of Benjamini and Hochberg. Blue circles and brown diamonds represent the top 15 most significant lipid species associated with BMI (p < 10–217) and mBMIΔ (p < 10–157), respectively. Each data point in (c) and (d) represent coefficients (% differences) per unit of BMI (c) or mBMIΔ (d) and the error bars represent 95% confidence intervals (CI). e The correlation between effect sizes of each lipid associated with BMI (x-axis) and with mBMIΔ (y-axis). Additional details are shown in Supplementary Data 1 and 2. AC acylcarnitine, CE cholesteryl ester, Cer ceramide, COH cholesterol, DE dehydrocholesterol, dhCer dihydroceramide, DG diacylglycerol, GM1 GM1 ganglioside, GM3 GM3 ganglioside, HexCer monohexosylceramide, Hex2Cer dihexosylceramide, Hex3Cer trihexosylceramide, LPC lysophosphatidylcholine, LPC(O) lysoalkylphosphatidylcholine, LPC(P) lysoalkenylphosphatidylcholine, LPE lysophosphatidylethanolamine, LPE(P) lysoalkenylphosphatidylethanolamine, LPI lysophosphatidylinositol, PC phosphatidylcholine, PC(O) alkylphosphatidylcholine, PC(P) alkenylphosphatidylcholine, PE phosphatidylethanolamine, PE(O) alkylphosphatidylethanolamine, PE(P) alkenylphosphatidylethanolamine, PG phosphatidylglycerol, PI phosphatidylinositol, PS phosphatidylserine, SHexCer sulfatide, SM sphingomyelin, TG triacylglycerol, TG(O) alkyl-diacylglycerol.

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