Fig. 1: Analysis 1: Development of the molecular staging model to assign cycle stage for secretory stage samples only.
From: A molecular staging model for accurately dating the endometrial biopsy
Panel 1. Examples of regression spline fitting to expression data for individual genes from 96 endometrial samples taken between post-ovulatory days (POD) 1–14. Splines were fitted to a total of 20,067 genes. The error bands surrounding the regression lines represent the 95% confidence interval. Panel 2. Plots showing post-ovulatory time that gives lowest Mean Squared Error (MSE) using spline data for all 20,067 probes for 3 different endometrial samples (solid line). Dotted lines show POD estimates from 2 independent evaluations by experienced pathologists. Panel 3. Correlation between average POD from 2 or 3 independent pathology evaluations and the POD time at which the lowest MSE occurred. Panel 4. Correlation between the estimated POD from the POD secretory model and the estimated cycle time from the 3 stages secretory model. Source data are provided as a Source Data file.
