Fig. 4: Regional association plots and motif enrichment analysis.
From: Immunosuppression causes dynamic changes in expression QTLs in psoriatic skin
a Regional eQTL association plots of rs7435274-UGT2B7(top) and rs881712-CBR3(bottom), two eQTL interactions with eGenes overlapping with NRF2 gene set. b SPITS interaction with the UGT2B7(top), CBR3 (bottom) eQTLs plotted with respect to rs7435274, rs881712 genotypes, respectively. The middle line in the box plots show medians, and the hinges correspond to the 25th and 75th percentiles. The whiskers extend the largest and smallest value no further than 1.5 × IQR from the hinges (n = 375 samples). c The ARE motifs disrupted by interacting eQTLs. Arrows indicate positions of the motif disrupted by eSNPs in strong LD with the interaction eSNPs in UGT2B7 (left), CBR3 (right) eQTLs.
