Fig. 6: Workflow of this study.
From: Gut microbiota impacts bone via Bacteroides vulgatus-valeric acid-related pathways
517 peri-/post-menopausal Chinese women were randomly recruited from Guangzhou City in China. Their stool and blood samples were collected for metagenomics/targeted metabolomics/whole-genome sequencing. By performing various statistical association analyses for dual energy X-ray absorptiometry-derived BMD, several BMD-related bacterial species/SCFAs/GM functional capacity were identified. An independent cohort of US white people and MR analysis were used for validation/causality investigation. Finally, in vitro and in vivo functional experiments were performed to validate the findings.
