Table 2 Correlation between GM biodiversity and BMD variation

From: Gut microbiota impacts bone via Bacteroides vulgatus-valeric acid-related pathways

Phenotypes

Shannon index

Optimal Kernel

partial γ

p-value

q-value

p-value of MiRKAT

q-value of MiRKAT

UD-R BMD

−0.081

0.072

0.144

0.005

0.028

UD-U BMD

−0.098

0.029

0.093

0.014

0.028

UD-RU BMD

−0.097

0.031

0.093

0.010

0.028

HTOT BMD

−0.043

0.344

0.516

0.812

0.812

FN BMD

0.004

0.931

0.931

0.733

0.812

L1-L4 BMD

0.031

0.493

0.592

0.475

0.713

  1. Note: partial γ - coefficient for the correlation between the Shannon index and BMD variation with partial Spearman correlation analysis; p-value - p-value of the correlation coefficient γ (two-sided); q-value - false discovery rate of the partial Spearman correlation analysis; Optimal Kernel - optimal kernel based on weighted and unweighted UniFrac distance matrices and Bray-Curtis distance; p-value of MiRKAT - p-value of the association between GM biodiversity and BMD variation with MiRKAT (two-sided); q-value of MiRKAT - false discovery rate of the MiRKAT analyses.
  2. Bolded BMDs were the nominally significant ones associated with GM biodiversity (p-values < 0.05).
Back to article page