Fig. 2: PTBP1 and EMCV-IRES-DtoF form a compacted complex with pronounced conformational flexibility. | Nature Communications

Fig. 2: PTBP1 and EMCV-IRES-DtoF form a compacted complex with pronounced conformational flexibility.

From: Integrative solution structure of PTBP1-IRES complex reveals strong compaction and ordering with residual conformational flexibility

Fig. 2

a Structural ensemble of the PTBP1/EMCV-IRES-DtoF complex in a conformer population-weighted visualization (opacity corresponds to the population of each conformer). The 25 models of the ensemble were superimposed on RRM34. Two views related by a vertical rotation of 90° are shown. SLE and SLF can be positioned in cis or trans with respect to SLD, illustrated in schemes on the right. b, c Conformers representative of the two subclasses (cis and trans) in two views. d Overlay of the ensemble on RRM2 illustrating the conformational flexibility of RRM1 with respect to RRM2. e–k Examples of conformers showing different ways RRM1 and RRM2 can be spatially close within the PTBP1/EMCV-IRES-DtoF complex.

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